HLA-B27 is a blood test to look for a protein that is found on the surface of white blood cells. The protein is called human leukocyte antigen B27 (HLA-B27).
Human leukocyte antigens (HLAs) are proteins that help the body's immune system tell the difference between its own cells and foreign, harmful substances.
Your health care provider may order this test to help determine the cause of joint pain, stiffness, or swelling.
A normal (negative) result means HLA-B27 is absent.
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